Build-a-Grant, Section by Section
In this round-up are building blocks for key grant sections gathered from Edge for Scholars blogs. Some sections are specific to NIH, while others generalize to many sponsors.
A Blueprint for Execution: Like any builder, you’ll benefit from a solid plan. Check-out this overview for pacing your grant writing to completion.
The Latest: A new format for the NIH Biosketch and Other Support introduces minor changes effective May 25, 2021.
Specific Aims: Capture the reviewers’ attention and get them to turn the page.
- At this time, figures are permitted in Specific Aims. However, figures will soon be disallowed in abstracts.
- Consider yourself a salesperson:
- Proposing an observational study? Ace your aims with these protips.
Research Strategy: These three sections are the meat of major research proposals. Of these, data show the Approach drives reviewer scores.
1. Significance: Begin with stating the critical problem in the field and how you’ll address it, then briefly summarize the “rigor of prior research” to address Significance, NIH-style.
2. Innovation: Treat this section like a marketing pitch. Using fresh ideas like bullets, quotes, and vignettes prevent it from becoming dense text.
3. Approach: A sound approach is required for a smooth landing. This checklist provides a glidepath so you won’t crash on approach.
Clinical Trials & Human Subjects Participant Research: Definitions and requirements changed in 2018. Edge for Scholars summarized the major considerations. Also double-check your RFA designation regarding clinical trials (“optional”, “required”) and use the checklist tools to confirm how NIH will view your proposal.
- Am I doing human subjects research?
- Does your human subjects research study meet definition of clinical trial?
Responsible Conduct of Research: Career development awards require a page about the candidate’s intended training in the responsible conduct of research. Also, refer to NIH’s RCR page (K awards, F awards) for key verbiage and elements to include.
- You can probably count much of what you already do.
- You need not include an exhaustive grocery list of every possible opportunity.
Rigor, Reproducibility, & Transparency: A newer requirement that you may be encountering for the first time. This also includes validation of biological samples. See also NIH’s RRT descriptions.
- There is some overlap with RCR activities and Approach checklist items
- Benefits for you: activities you are already doing may satisfy more than one are requirement, e.g., seminars, mentor meetings, validation of research materials.
- Benefits for the reviewer: thoughtfully repeat (or reference the earlier mentions) the qualifying activities in each section to help reviewers find items they are required to find.